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Second mitochondria-derived activator of caspases : ウィキペディア英語版 | Diablo homolog
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the ''DIABLO'' (direct IAP binding protein with low pI) gene on chromosome 12.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56616 )〕 DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis.〔 Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.〔 ==Structure==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Diablo homolog」の詳細全文を読む
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